期刊
MARINE DRUGS
卷 10, 期 12, 页码 2741-2748出版社
MDPI AG
DOI: 10.3390/md10122741
关键词
Cespitularia; cytotoxicity; diterpenoid; HCT 116 cells; alcyonolide
资金
- Japanese Government (Ministry of Education, Culture, Sports, Science, and Technology)
Five new diterpenoids 1-5 were isolated from an Okinawan soft coral, Cespitularia sp., together with the known diterpenoid, alcyonolide (6). New diterpenoid structures were elucidated by spectroscopic methods and by comparison of their NMR data with those of related compounds. Alcyonolide (6) was cytotoxic against HCT 116 cells (IC50 5.85 mu M), while these new diterpenoids 1-5 were much less active (IC50 28.2-91.4 mu M).
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