期刊
MARINE DRUGS
卷 9, 期 12, 页码 2705-2716出版社
MDPI
DOI: 10.3390/md9122705
关键词
soft coral; Lobophytum crassum; cytotoxicity
资金
- National Science Council of Taiwan [NSC99-2628-B-110-002-MY3]
Chemical investigation of the Dongsha Atoll soft coral Lobophytum crassum has afforded four new cembranoids, crassumols A-C (1-3) and 13-acetoxysarcophytoxide (4). The structures of these isolated compounds were elucidated by extensive NMR and HRESIMS experiments. The cytotoxicity and anti-HCMV (Human cytomegalovirus) activities of 1-4 were evaluated in vitro. Compound 4 exhibited cytotoxicity against A-549 (human lung carcinoma) cell line with an ED50 of 3.6 mu g/mL.
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