期刊
MARINE DRUGS
卷 9, 期 8, 页码 1368-1378出版社
MDPI
DOI: 10.3390/md9081368
关键词
Aspergillus terreus; high salinity metabolites; terremides A and B; terrelactone A
资金
- Special Fund for Marine Scientific Research in the Public Interest of China [2010418022-3]
- National Basic Research Program of China [2010CB833800]
- National Natural Science Foundation of China [30973680, 30670219]
- PCSIRT [IRT0944]
To investigate the structurally novel and bioactive natural compounds from marine-derived microorganisms under high salinity, the fungus Aspergillus terreus PT06-2 was isolated from the sediment of the Putian Sea Saltern, Fujian, China. Three new compounds, terremides A (1) and B (2) and terrelactone A (3), along with twelve known compounds (4-15) were isolated and identified from the fermentation broth of A. terreus PT06-2 at 10% salinity. Among these metabolites, compounds 4 and 15 only produced in the 10% salinity culture, were identified as methyl 3,4,5-trimethoxy-2-(2-(nicotinamido) benzamido) benzoate, and (+)-terrein, respectively. The new compounds 1 and 2 exhibited antibacterial activity against Pseudomonas aeruginosa and Enterobacter aerogenes with MIC values of 63.9 and 33.5 mu M, respectively. Compounds 5 showed moderate anti-H1N1 activity and lower cytotoxicity with IC50 and CC50 values of and 143.1 and 976.4 mu M, respectively.
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