期刊
MARINE DRUGS
卷 9, 期 5, 页码 844-851出版社
MDPI AG
DOI: 10.3390/md9050844
关键词
balticolid; antiviral; herpes simplex virus; marine fungi
A new 12-membered macrolide, balticolid (1) was isolated from the EtOAc extract of the culture broth of fungal strain 222 belonging to the Ascomycota, which was found on driftwood collected from the coast of the Greifswalder Bodden, Baltic Sea, Germany. The structure of balticolid was determined to be (3R, 11R), (4E, 8E)-3-hydroxy-11-methyloxacyclododeca-4,8-diene-1,7-dione using extensive spectral data as well as the modified Mosher ester method. Balticolid (1) displayed anti-HSV-1 activity with an IC(50) value of 0.45 mu M.
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