期刊
MARINE DRUGS
卷 9, 期 8, 页码 1403-1418出版社
MDPI AG
DOI: 10.3390/md9081403
关键词
briarane diterpenoids; biological activity; structure elucidation; gorgonian; Dichotella gemmacea
资金
- Natural Science Foundation of China [30873200, 41076082]
- STCSM [10431902400]
- Shanghai Leading Academic Discipline Project [B906]
- Shanghai Pujiang Program [PJ2008]
- National Office for Research and Technology
- Hungarian Scientific Research Fund [NKTH, K-68429, OTKA, K-81701, TAMOP 4.2.1./B-09/1/KONV-2010-0007]
- Janos Bolyai Foundation
Six new (3Z,5E)-11,20-epoxybriara-3,5-dien-7,18-olide diterpenoids, gemmacolides N-S (1-6), were isolated together with four known analogues, juncenolide D, and juncins R, S and U (7-10), from the South China Sea gorgonian Dichotella gemmacea. The structures of the new compounds were elucidated by the detailed analysis of spectroscopic data in combination with the comparison with reported data. The absolute configuration of 1 was determined by a TDDFT calculation of its solution ECD spectrum, affording the determination of absolute configuration of other analogues by simply comparing their ECD spectra with that of 1. The cytotoxic and antimicrobial activities of these compounds were evaluated. In preliminary in vitro bioassays, compounds 4, 5, 6, 8 and 9 showed cytotoxicity against A549 and MG63, while compounds 1, 2, 4, 7-10 showed antimicrobial activity against the fungus Septoria tritici and the bacterium Escherichia coli.
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