期刊
MARINE DRUGS
卷 9, 期 5, 页码 832-843出版社
MDPI
DOI: 10.3390/md9050832
关键词
endophytic fungus; Alternaria sp.; bianthraquinone; alterporriol; cytotoxicity
资金
- 863 Foundation of China [2006AA09Z422, 2007AA]
- National Natural Science Foundation of China [20772162, 20972197]
- National Science Foundation of Guangdong Province, China [91510227501000055]
- Science & Technology Plan Project of Guangdong Province of China [2010B030600004]
Three new bianthraquinone derivatives, alterporriol K (1), L (2) and M (3), along with six known compounds were obtained from extracts of the endophytic fungus Alternaria sp. ZJ9-6B, isolated from the mangrove Aegiceras corniculatum collected in the South China Sea. Their structures were elucidated by one- and two-dimensional NMR spectroscopy, MS data analysis and circular dichroism measurements. Compounds 1, 2 and 3 were first isolated alterporriols with a C-2-C-2' linkage. The crystallographic data of tetrahydroaltersolanol B (7) was reported for the first time. In the primary bioassays, alterporriol K and L exhibited moderate cytotoxic activity towards MDA-MB-435 and MCF-7 cells with IC50 values ranging from 13.1 to 29.1 mu M.
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