期刊
MARINE DRUGS
卷 8, 期 4, 页码 835-880出版社
MDPI
DOI: 10.3390/md8040835
关键词
salinosporamide A; marizomib; NPI-0052; proteasome inhibitor; total synthesis; semi-synthesis; natural products chemistry; fermentation; mutasynthesis; precursor-directed biosynthesis; structure-activity relationships; analogs
The salinosporamides are potent proteasome inhibitors among which the parent marine-derived natural product salinosporamide A (marizomib; NPI-0052; 1) is currently in clinical trials for the treatment of various cancers. Methods to generate this class of compounds include fermentation and natural products chemistry, precursor-directed biosynthesis, mutasynthesis, semi-synthesis, and total synthesis. The end products range from biochemical tools for probing mechanism of action to clinical trials materials; in turn, the considerable efforts to produce the target molecules have expanded the technologies used to generate them. Here, the full complement of methods is reviewed, reflecting remarkable contributions from scientists of various disciplines over a period of 7 years since the first publication of the structure of 1.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据