期刊
MARINE DRUGS
卷 8, 期 2, 页码 347-358出版社
MDPI
DOI: 10.3390/md8020347
关键词
meroterpene; methoxyconidiol; epiconicol; didehydroconicol; antiproliferative activity
资金
- La Ligue Contre le Cancer (Comit, des Pyrenees Orientales)
- Agence Nationale de la Recherche (ANR) [ANR-06-BDIV-001-04]
Meroterpenes are compounds of mixed biogenesis, isolated from plants, microorganisms and marine invertebrates. We have previously isolated and determined the structure for a series of meroterpenes extracted from the ascidian Aplidium aff. densum. Here, we demonstrate the chemical synthesis of three of them and their derivatives, and evaluate their biological activity on two bacterial strains, on sea urchin eggs, and on cancerous and healthy human cells.
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