期刊
MARINE DRUGS
卷 8, 期 11, 页码 2837-2848出版社
MDPI
DOI: 10.3390/md8112848
关键词
soft coral; Lobophytum pauciflorum; lobophytones O-T; structure elucidation; NO inhibition; antibiotic activity
资金
- National Hi-Tech Development Project (863 project) [2010DFA31610, 2007AA09Z448, 2008AA09Z405]
- NSFC [30930109]
- National Key Innovation Project [2009ZX09501-014, DYXM-115-02-2-09]
Chemical examination of a Chinese soft coral Lobophytum pauciflorum resulted in the isolation of five new biscembranoids named lobophytones O-S (1-5) and a new monomeric cembrane lobophytone T (6). The structures of the new compounds were elucidated by interpretation of 1D and 2D NMR (COSY, HSQC, HMBC, and NOESY) spectroscopic data in association with MS and IR data. Lobophytone Q showed significant inhibition against lipopolysaccharide (LPS)-induced nitric oxide (NO) release in mouse peritoneal macrophages, while lobophytones Q and T showed inhibitory activities against the bacteria S. aureus and S. pneumoniae.
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