期刊
MARINE DRUGS
卷 7, 期 4, 页码 528-538出版社
MDPI
DOI: 10.3390/md7040528
关键词
lyngbyastatins; cyanobacteria; Lyngbya semiplena; cyclic depsipeptides; elastase inhibitors
资金
- NIGMS NIH HHS [P41GM086210, P41 GM086210] Funding Source: Medline
Investigation of an extract from the marine cyanobacterium Lyngbya semiplena, collected in Tumon Bay, Guam, led to the identification of three new cyclodepsipeptides, lyngbyastatins 8-10 (1-3). The structures of 1-3 were determined by NMR, MS, ESIMS fragmentation and chemical degradation. Compounds 1-3 are closely related to lyngbyastatins 4-7. Like the latter compounds, we found 1-3 to inhibit porcine pancreatic elastase, with IC50 values of 123 nM, 210 nM and 120 nM, respectively.
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