期刊
MARINE DRUGS
卷 6, 期 4, 页码 578-586出版社
MDPI
DOI: 10.3390/md6040578
关键词
pyrroloquinolines; phenylpyrroles; gliding bacteria; Rapidithrix thailandica; acetylcholinesterase inhibitors
资金
- Thailand Research Fund [DBG5080024, MRG4880154]
- TRF/BIOTEC Special Program for Biodiversity Research and Training Program [BRT T_650006]
- Academic Excellence Enhancing Program in Pharmaceutical Sciences
- Center of Excellence, Commission on Higher Education, Thailand
Acetylcholinesterase-inhibiting activity of marinoquinoline A (1), a new pyrroloquinoline from a novel species of a marine gliding bacterium Rapidithrix thailandica, was assessed (IC50 4.9 mu M). Two related pyrrole derivatives, 3-(2'-aminophenyl)- pyrrole (3) and 2,2-dimethyl-pyrrolo-1,2-dihydroquinoline (4), were also isolated from two other strains of R. thailandica. The isolation of 3 from a natural source is reported here for the first time. Compound 4 was proposed to be an isolation artifact derived from 3. The two isolated compounds were virtually inactive in the acetylcholinesterase-inhibitory assay (enzyme inhibition <30% at 0.1 g L-1).
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