期刊
MARINE BIOTECHNOLOGY
卷 13, 期 1, 页码 1-11出版社
SPRINGER
DOI: 10.1007/s10126-010-9294-y
关键词
Deep-sea hydrothermal vent; Extremophile; Natural product; Secondary metabolite
资金
- Division of Cancer Treatment, Diagnosis and Centers, National Cancer Institute, DHHS [R01 CA90441-01-05, 2R56 CA090441-06A1, 5R01 CA090441-07]
- Arizona Biomedical Research Research Commission
Microbes from extreme environments do not necessarily require extreme culture conditions. Perhaps the most extreme environments known, deep-sea hydrothermal vent sites, support an incredible array of archaea, bacteria, and fungi, many of which have now been cultured. Microbes cultured from extreme environments have not disappointed in the natural products arena; diverse bioactive secondary metabolites have been isolated from cultured extreme-tolerant microbes, extremophiles, and deep-sea microbes. The contribution of vent microbes to our arsenal of natural products will likely grow, given the culturability of vent microbes; their metabolic, physiologic, and phylogenetic diversity; numerous reports of bioactive natural products from microbes inhabiting high acid, high temperature, or high pressure environments; and the recent isolation of new chroman derivatives and siderophores from deep-sea hydrothermal vent bacteria.
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