期刊
RENAL FAILURE
卷 37, 期 9, 页码 1430-1434出版社
TAYLOR & FRANCIS LTD
DOI: 10.3109/0886022X.2015.1074473
关键词
Chronic kidney disease; hemodialysis; inflammation; peripheral blood; physical exercise
资金
- Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior (PROSUP/CAPES/Brazil)
- Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq) (MCTI/CNPQ/Universal)
Background: Immunological dysfunctions and a pro-inflammatory environment are associated with higher risk of cardiovascular diseases in chronic kidney disease (CKD). Physical exercise can be an important anti-inflammatory strategy, but the effects in CKD remain poorly investigated. Objective: Evaluate the acute inflammatory response to intradialytic exercise in the peripheral blood of individuals with CKD. Methods: Nine patients, of both genders, with CKD and allocated in the ambulatory of hemodialysis of Hospital Ernesto Dornelles (Brazil), performed two sessions of hemodialysis (HD) in random form: aerobic intradialytic exercise sessions (EX, 20min of moderate exercise in cycle-ergometer) and a control hemodialysis session (CON). Peripheral blood collection was made at the baseline, during and immediately after HD to evaluate the cytokine profile: interleukin-6, interleukin-10 (IL-10), interleukin-17a (IL-17a), interferon-gamma (INF-) and tumoral necrosis factor-alpha (TNF-). Results: INF- decreased during HD when compared with the pre moment in both sessions, while an increase in post HD was only found in the CON session. IL-17 was higher in post when compared with during HD in both sessions. In addition to the time effect, IL-10 presented a timexgroup interaction and the relative changes were significantly higher in EX when compared with the CON session. The relative changes in TNF- tended to be higher in CON when compared with EX immediately post HD session. Conclusions: These data indicate that 20min of intradialytic exercise have modest effect in systemic inflammation. However, the significant increase in IL-10 may indicate an immunoregulatory effect of physical exercise.
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