期刊
MALARIA JOURNAL
卷 13, 期 -, 页码 -出版社
BMC
DOI: 10.1186/1475-2875-13-81
关键词
Africa; Malaria; Medicinal plants; Natural products; Traditional medicine
资金
- Lhasa Ltd, Leeds, UK through the Chemical and Bioactivity Information Centre (CBIC), University of Buea, Cameroon
Malaria is currently a public health concern in many countries in the world due to various factors which are not yet under check. Drug discovery projects targeting malaria often resort to natural sources in the search for lead compounds. A survey of the literature has led to a summary of the major findings regarding plant-derived compounds from African flora, which have shown anti-malarial/antiplasmodial activities, tested by in vitro and in vivo assays. Considerations have been given to compounds with activities ranging from very active to weakly active, leading to > 500 chemical structures, mainly alkaloids, terpenoids, flavonoids, coumarins, phenolics, polyacetylenes, xanthones, quinones, steroids and lignans. However, only the compounds that showed anti-malarial activity, from very active to moderately active, are discussed in this review.
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