期刊
MAGNETIC RESONANCE IN MEDICINE
卷 73, 期 3, 页码 995-1004出版社
WILEY-BLACKWELL
DOI: 10.1002/mrm.25200
关键词
diffusion; cardiac; parallel imaging; simultaneous multislice; blipped CAIPI; multiband
资金
- National Institute for Health Research
- Oxford Biomedical Research Centre Programme
- British Heart Foundation Fellowship [FS/10/002/28078, RG/11/9/28921]
- Wellcome Trust [WT100092MA]
- MRC [G0601490] Funding Source: UKRI
- British Heart Foundation [FS/10/002/28078, RG/11/9/28921, FS/14/17/30634] Funding Source: researchfish
- Medical Research Council [G0601490] Funding Source: researchfish
PurposeTo demonstrate the feasibility of accelerating measurements of cardiac fiber structure using simultaneous multislice (SMS) imaging. MethodsSMS excitation with a blipped controlled aliasing (CAIPI) readout was incorporated into a diffusion-encoded stimulated echo pulse sequence to obtain diffusion measurements in three separate slices of the heart (8-mm thickness, 12-mm gap). A novel image entropy-based method for removing image ghosts in blipped CAIPI acquisitions is also introduced that enables SMS imaging of closely spaced slices in the heart. ResultsThe average retained signal-to-noise ratio (SNR) using this acquisition scheme is 70%5%, higher than the standard 1/3=57% SNR penalty with three-fold acceleration. No significant difference was observed in the apparent diffusion coefficient and helix angle diffusion parameters between a time-equivalent conventional single-slice scan and the three-fold accelerated SMS acquisition. A 10% mean bias was observed in fractional anisotropy between single-slice and SMS acquisitions. ConclusionThe new sequence was used to obtain high-quality diffusion measurements in three closely spaced cardiac slices in a clinically feasible nine breath-hold examination. The accelerated multiband sequence is anticipated to improve quantitative measurements of cardiac microstructure by reducing the number of breath-holds required for the scan, making it practical to incorporate diffusion tensor measurements within a comprehensive clinical examination. Magn Reson Med 73:995-1004, 2015. (c) 2014 Wiley Periodicals, Inc.
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