The Effect of Low b-Values on the Intravoxel Incoherent Motion Derived Pseudodiffusion Parameter in Liver

PurposeTo examine the effect of low b-values (0<50 s/mm(2)) on the calculation of the intravoxel incoherent motion (IVIM) derived pseudodiffusion parameter in the normal liver. MethodsSimulations were performed to examine the effects of adding low b-values on the pseudodiffusion parameter. Low b-values were cumulatively added to the distribution and the IVIM signal was generated with varying pseudodiffusion values. The signal was fit with the IVIM model after the addition of Gaussian noise, and the simulated values were compared with the true values. In addition, the livers of eight control subjects were imaged using respiratory-triggered DWI. Pseudodiffusion was calculated with and without low b-values and compared. ResultsPseudodiffusion tended to be underestimated when low b-values were not included in the b-value distribution as predicted by simulations and confirmed with in vivo imaging. The number of outlier values was also reduced as more low b-values were added. ConclusionIn conclusion, this study showed pseudodiffusion in the liver tended to be underestimated when too few low b-values (0<50 s/mm(2)) were included in the distribution. Therefore, it is recommended to include at least two low b-values when performing liver IVIM studies. Magn Reson Med 73:306-311, 2015. (c) 2014 Wiley Periodicals, Inc.