期刊
MAGNETIC RESONANCE IN MEDICINE
卷 70, 期 2, 页码 341-347出版社
WILEY-BLACKWELL
DOI: 10.1002/mrm.24831
关键词
T-1 mapping; super-paramagnetic iron oxide nanoparticles; sweep imaging with Fourier transformation; positive contrast
资金
- NIH [P41RR008079, P41EB015894, R21CA139688, KL2RR033182]
- National Center for Research Resources [S10RR023706]
Purpose T-1 quantification of contrast agents, such as super-paramagnetic iron oxide nanoparticles, is a challenging but important task inherent to many in vivo applications in magnetic resonance imaging. In this work, a sweep imaging with Fourier transformation using variable flip angles (VFAs-SWIFT) method was proposed to measure T-1 of aqueous super-paramagnetic iron oxide nanoparticle suspensions. Methods T-1 values of various iron concentrations (from 1 to 7 mM) were measured using VFA-SWIFT and three-dimensional spoiled gradient-recalled echo with VFAs (VFA-SPGR) sequences on a 7 T MR scanner. For validation, T-1 values were also measured using a spectroscopic inversion-recovery sequence on a 7 T spectrometer. Results VFA-SWIFT demonstrated its advantage for quantifying T-1 of highly concentrated aqueous super-paramagnetic iron oxide nanoparticle suspensions, but VFA-SPGR failed at the higher end of iron concentrations. Both VFA-SWIFT and VFA-SPGR yielded linear relationships between the relaxation rate and iron concentrations, with relaxivities of 1.006 and 1.051 s(-1) mM(-1) at 7 T, respectively, in excellent agreement with the spectroscopic measurement of 1.019 s(-1) mM(-1). Conclusion VFA-SWIFT is able to achieve accurate T-1 quantification of aqueous super-paramagnetic iron oxide nanoparticle suspensions up to 7 mM. Magn Reson Med 70:341-347, 2013. (c) 2013 Wiley Periodicals, Inc.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据