期刊
MAGNETIC RESONANCE IN MEDICINE
卷 71, 期 5, 页码 1841-1853出版社
WILEY
DOI: 10.1002/mrm.24822
关键词
CEST; chemical exchange saturation transfer; tumor; Lorentzian; amide; amine; aliphatic
资金
- Ontario Institute of Cancer Research
- Canadian Institute of Health Research
PurposeTo evaluate the performance of endogenous chemical exchange saturation transfer (CEST) spectra and derived maps in a longitudinal study of tumor xenografts to ascertain the role of CEST parameters in describing tumor progression and in distinguishing between tumor, muscle, and necrosis. MethodsCEST spectra of 24 mice with tumor xenografts (20 LLC and 4 MDA) were acquired at three time-points. We employed a novel method of decomposing the CEST spectrum into a sum of four Lorentzian shapes, each with a corresponding measured amplitude, width and frequency offset. This semi-quantitative method is an improvement over techniques which simply assess the asymmetry in the spectrum for the presence of CEST, due to the fact that it is not confounded by CEST peaks on opposing sides of the direct effect. The CEST images were compared to several other commonly employed contrast mechanisms: T-1 relaxation, T-2 relaxation, diffusion (ADC), and magnetization transfer (MT). ResultsTumor spectra had distinct CEST peaks corresponding to the presence of hydrogen exchange between free water and amide, amine, and aliphatic groups. All three CEST peaks (amide, amine, and aliphatic) were larger in the tumor tissue as compared with the adjacent healthy muscle. ConclusionsCEST contrast (particularly the amine peak amplitude) performed especially well in distinguishing areas of apoptosis and/or necrosis from actively progressing tumor, as validated by histology. Magn Reson Med 71:1841-1853, 2014. (c) 2013 Wiley Periodicals, Inc.
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