期刊
MAGNETIC RESONANCE IN MEDICINE
卷 69, 期 2, 页码 545-552出版社
WILEY
DOI: 10.1002/mrm.24535
关键词
fatty liver; proton density fat-fraction; diffusion weighted imaging; apparent diffusion coefficient
资金
- NIH [R01 DK083380, R01 DK088925, RC1 EB010384, R01 DK096169]
- WARF Accelerator Grant program
- GE Healthcare
Purpose: Triglyceride signal contained in peaks near the water peak remains unsuppressed by conventional fat suppression techniques used in diffusion-weighted imaging. In this work, we investigated the dependence of the apparent diffusion coefficient (ADC) on liver fat content and whether it is confounded by fat signal. Methods: 43 patients underwent liver diffusion-weighted imaging (b = 0, 500 s/mm2) and single-voxel MR-spectroscopy. Proton density fat-fraction (PDFF; range 0.2334.5%) was measured from MR-spectroscopy. A theoretical model was developed to account for the effects of fat on observed ADC, and used to correct the ADC. Linear correlation analysis was performed to assess the relationship between PDFF and ADC before and after correction. Results: Linear correlation analysis showed an inverse dependence between observed ADC and PDFF before correction (r2 = 0.132; P = 0.017), and no dependence after correction (r2 = 0.033; P = 0.24). Conclusion: The observed decrease in ADC in patients with fatty liver is, at least in part, artifactual due to residual fat signal near the water peak. Magn Reson Med, 2013. (C) 2012 Wiley Periodicals, Inc.
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