期刊
MAGNETIC RESONANCE IN MEDICINE
卷 70, 期 4, 页码 1153-1159出版社
WILEY-BLACKWELL
DOI: 10.1002/mrm.24547
关键词
longitudinal relaxation; in vitro blood; 7 T; hematocrit; oxygen saturation fraction; oxygen partial pressure; mean corpuscular hemoglobin concentration; plasma osmolality
资金
- National Center for Research Resources
- National Institute of Biomedical Imaging and Bioengineering of the National Institutes of Health [NIH P41 EB015909]
Knowledge of blood (H2O)-H-1 T-1 is critical for perfusion-based quantification experiments such as arterial spin labeling and cerebral blood volume-weighted MRI using vascular space occupancy. The dependence of blood (H2O)-H-1 T-1 on hematocrit fraction (Hct) and oxygen saturation fraction (Y) was determined at 7 T using in vitro bovine blood in a circulating system under physiological conditions. Blood (H2O)-H-1 R-1 values for different conditions could be readily fitted using a two-compartment (erythrocyte and plasma) model, which are described by a monoexponential longitudinal relaxation rate constant dependence. It was found that T-1 = 2171 +/- 39 ms for Y = 1 (arterial blood) and 2010 +/- 41 ms for Y = 0.6 (venous blood), for a typical Hct of 0.42. The blood (H2O)-H-1 T-1 values in the normal physiological range (Hct from 0.35 to 0.45, and Y from 0.6 to 1.0) were determined to range from 1900 to 2300 ms. The influence of oxygen partial pressure (pO(2)) and the effect of plasma osmolality for different anticoagulants were also investigated. It is discussed why blood (H2O)-H-1 T-1 values measured in vivo for human blood may be about 10-20% larger than found in vitro for bovine blood at the same field strength. Magn Reson Med, 70:1153-1159, 2013. (c) 2012 Wiley Periodicals, Inc.
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