期刊
MAGNETIC RESONANCE IN MEDICINE
卷 67, 期 3, 页码 614-621出版社
WILEY-BLACKWELL
DOI: 10.1002/mrm.24128
关键词
T2 relaxometry; white matter; myelin water fraction; spiral sampling; 3D acquisition
Quantitative assessment of myelination is important for characterizing tissue damage and evaluating response to therapy in white matter diseases such as multiple sclerosis. Conventional multicomponent T2 relaxometry based on the two-dimensional (2D) multiecho spin echo sequence is a promising method to measure myelin water fraction, but its clinical utility is impeded by the prohibitively long data acquisition and limited brain coverage. The objective of this study was to develop a signal-to-noise ratio efficient 3D T2prep spiral gradient echo (3D SPIRAL) sequence for full brain T2 relaxometry and to validate this sequence using 3D multiecho spin echo as reference standard in healthy brains at 1.5 T. 3D SPIRAL was found to provide similar myelin water fraction in six selected white and gray matter areas using region-of-interest signal averaging analysis (N = 7, P > 0.05). While 3D multiecho spin echo only provided partial brain coverage, 3D SPIRAL enabled whole brain coverage with a fivefold higher acquisition speed per imaging slice and similar signal-to-noise ratio efficiency. Both 3D sequences provided superior signal-to-noise ratio efficiency when compared to the conventional 2D multiecho spin echo approach. Magn Reson Med, 2012. (c) 2011 Wiley Periodicals, Inc.
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