期刊
MAGNETIC RESONANCE IN MEDICINE
卷 69, 期 1, 页码 171-178出版社
WILEY
DOI: 10.1002/mrm.24211
关键词
shutter-speed; DCE-MRI; prostate
资金
- NIH [R01-EB00422, R01-NS40801, R01-CA120861, U01-CA154602]
- RSNA Research and Education Foundation (Research Medical Student Grant) [RMS0801]
- Medical Research Foundation of Oregon
The feasibility of shutter-speed model dynamic-contrast-enhanced MRI pharmacokinetic analyses for prostate cancer detection was investigated in a prebiopsy patient cohort. Differences of results from the fast-exchange-regime-allowed (FXR-a) shutter-speed model version and the fast-exchange-limit-constrained (FXL-c) standard model are demonstrated. Although the spatial information is more limited, postdynamic-contrast-enhanced MRI biopsy specimens were also examined. The MRI results were correlated with the biopsy pathology findings. Of all the model parameters, region-of-interest-averaged Ktrans difference [?Ktrans = Ktrans(FXR-a) - Ktrans(FXL-c)] or two-dimensional Ktrans(FXR-a) vs. kep(FXR-a) values were found to provide the most useful biomarkers for malignant/benign prostate tissue discrimination (at 100% sensitivity for a population of 13, the specificity is 88%) and disease burden determination. (The best specificity for the fast-exchange-limit-constrained analysis is 63%, with the two-dimensional plot.) Ktrans and kep are each measures of passive transcapillary contrast reagent transfer rate constants. Parameter value increases with shutter-speed model (relative to standard model) analysis are larger in malignant foci than in normal-appearing glandular tissue. Pathology analyses verify the shutter-speed model (FXR-a) promise for prostate cancer detection. Parametric mapping may further improve pharmacokinetic biomarker performance. Magn Reson Med, 2013. (c) 2012 Wiley Periodicals, Inc.
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