期刊
MAGNETIC RESONANCE IN MEDICINE
卷 67, 期 1, 页码 42-49出版社
WILEY
DOI: 10.1002/mrm.22970
关键词
T2 relaxation under spin tagging; arterial spin labeling; cerebral blood flow; hypoxia; normoxia
资金
- NIH [R01 MH084021, R01 NS067015, R01 AG033106, R41 RR015241]
Recently, a T2-Relaxation-Under-Spin-Tagging (TRUST) MRI technique was developed to quantitatively estimate blood oxygen saturation fraction (Y) via the measurement of pure blood T2. This technique has shown promise for normalization of fMRI signals, for the assessment of oxygen metabolism, and in studies of cognitive aging and multiple sclerosis. However, a human validation study has not been conducted. In addition, the calibration curve used to convert blood T2 to Y has not accounted for the effects of hematocrit (Hct). In this study, we first conducted experiments on blood samples under physiologic conditions, and the Carr-Purcell-Meiboom-Gill T2 was determined for a range of Y and Hct values. The data were fitted to a two-compartment exchange model to allow the characterization of a three-dimensional plot that can serve to calibrate the in vivo data. Next, in a validation study in humans, we showed that arterial Y estimated using TRUST MRI was 0.837 +/- 0.036 (N=7) during the inhalation of 14% O2, which was in excellent agreement with the gold-standard Y values of 0.840 +/- 0.036 based on Pulse-Oximetry. These data suggest that the availability of this calibration plot should enhance the applicability of T2-Relaxation-Under-Spin-Tagging MRI for noninvasive assessment of cerebral blood oxygenation. Magn Reson Med, 2011. (C) 2011 Wiley-Liss, Inc.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据