期刊
MAGNETIC RESONANCE IN MEDICINE
卷 66, 期 6, 页码 1722-1730出版社
WILEY
DOI: 10.1002/mrm.22968
关键词
oximetry; tissue oxygen tension; fluorine MRI; hexafluorobenzene
资金
- Foundation for Anesthesia Education and Research
- SW-SAIRP [U24 CA126608]
- NIH [R01, CA139043-01A1]
Measurement of individual organ tissue oxygen levels can provide information to help evaluate and optimize medical interventions in many areas including wound healing, resuscitation strategies, and cancer therapeutics. Echo planar F-19 MRI has previously focused on tumor oxygen measurement at low oxygen levels (pO(2)) <30 mmHg. It uses the linear relationship between spin-lattice relaxation rate (R-1) of hexafluorobenzene (HFB) and pO(2). The feasibility of this technique for a wider range of pO(2) values and individual organ tissue pO(2) measurement was investigated in a rat model. Spin-lattice relaxation times (T-1 = 1/R-1) of hexafluorobenzene were measured using F-19 saturation recovery echo planar imaging. Initial in vitro studies validated the linear relationship between R-1 and pO(2) from 0 to 760 mmHg oxygen partial pressure at 25, 37, and 41 degrees C at 7 Tesla for hexafluorobenzene. In vivo experiments measured rat tissue oxygen (ptO2) levels of brain, kidney, liver, gut, muscle, and skin during inhalation of both 30 and 100% oxygen. All organ ptO(2) values significantly increased with hyperoxia (P < 0.001). This study demonstrates that F-19 MRI of hexafluorobenzene offers a feasible tool to measure regional ptO2 in vivo, and that hyperoxia significantly increases ptO2 of multiple organs in a rat model. Magn Reson Med 66:1722-1730, 2011. (C) 2011 Wiley Periodicals, Inc.
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