期刊
MAGNETIC RESONANCE IN MEDICINE
卷 67, 期 4, 页码 1106-1113出版社
WILEY-BLACKWELL
DOI: 10.1002/mrm.23100
关键词
CEST; multicolor MR imaging; molecular imaging; liposome contrast agent; lymph node imaging
资金
- NIH [R21 EB005252, EB008769-01A1, NS065284-01, R01 EB012590, EB015031, EB015032]
A variety of (super)paramagnetic contrast agents are available for enhanced MR visualization of specific tissues, cells, or molecules. To develop alternative contrast agents without the presence of metal ions, liposomes were developed containing simple bioorganic and biodegradable compounds that produce diamagnetic chemical exchange saturation transfer MR contrast. This diamagnetic chemical exchange saturation transfer contrast is frequency-dependent, allowing the unique generation of multicolor images. The contrast can be turned on and off at will, and standard images do not show the presence of these agents. As an example, glycogen, L-arginine, and poly-L-lysine were encapsulated inside liposomes and injected intradermally into mice to image the lymphatic uptake of these liposomes. Using a frequency-dependent acquisition scheme, it is demonstrated that multicolor MRI can differentiate between different contrast particles in vivo following their homing to draining lymph nodes. Being nonmetallic and bioorganic, these diamagnetic chemical exchange saturation transfer liposomes form an attractive novel platform for multicolor imaging in vivo. Magn Reson Med 67:1106-1113, 2012. (c) 2011 Wiley Periodicals, Inc.
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