期刊
MAGNETIC RESONANCE IN MEDICINE
卷 65, 期 4, 页码 1173-1183出版社
WILEY-BLACKWELL
DOI: 10.1002/mrm.22641
关键词
arterial spin labeling; cerebral blood flow; partial volume effects; perfusion MRI; white matter
资金
- Engineering and Physical Sciences Research Council, UK
- Clarendon Fund
- Dunhill Medical Trust
- Natural Sciences and Engineering Council of Canada
- Heart and Stroke Foundation of Canada
- MRC [G0802179] Funding Source: UKRI
- Engineering and Physical Sciences Research Council [EP/C539788/1] Funding Source: researchfish
- Medical Research Council [G0802179] Funding Source: researchfish
The accuracy of cerebral blood flow (CBF) estimates from arterial spin labeling (ASL) is affected by the presence of both gray matter (GM) and white matter within any voxel. Recently a partial volume (PV) correction method for ASL has been demonstrated (Asllani et al. Magn Reson Med 2008; 60:1362-1371), where PV estimates were used with a local linear regression to separate the GM and white matter ASL signal. Here a new PV correction method for multi-inversion time ASL is proposed that exploits PV estimates within a spatially regularized kinetic curve model analysis. The proposed method exploits both PV estimates and the different kinetics of the ASL signal arising from GM and white matter. The new correction method is shown, on both simulated and real data, to provide correction of GM CBF comparable to a linear regression approach, whilst preserving greater spatial detail in the CBF image. On real data corrected GM CBF values were found to be largely independent of GM PV, implying that the correction had been successful. Increases of mean GM CBF after correction of 69-80% were observed. Magn Reson Med 65:1173-1183, 2011. (C) 2011 Wiley-Liss, Inc.
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