期刊
MAGNETIC RESONANCE IN MEDICINE
卷 66, 期 5, 页码 1267-1274出版社
WILEY
DOI: 10.1002/mrm.22905
关键词
dynamic contrast enhanced (DCE) MRI; arterial input function; phase signal; prostate cancer
Dynamic contrast-enhanced (DCE) MRI is useful for diagnosis, treatment monitoring and follow-up of prostate cancer. However, large differences have been reported in the parameter range of the transfer constant K-trans, making longitudinal studies and comparison of DCE-MRI findings between studies difficult. Large part of this inconsistency in K-trans values can be attributed to problems with the accurate measurement of the arterial input function (AIF) from the magnitude signal (AIF(MAGN)). Phase-based AIF measurements (AIF(PHASE)) have been proposed as a more robust alternative to AIFMAGN measurements. This study compares AIFPHASE with AIFs measured with DCE-CT (AIF(CT)), and the corresponding K-trans maps in 12 prostate cancer patients. The shape of AIF(PHASE) and AIF(CT) are similar, although differences in the peak height and peak width exist as a result of differences in injection protocol. No significant differences in K-trans values were found between the DCE-MRI and DCE-CT exams, with median K-trans values of 0.10 and 0.08 min(-1) for healthy peripheral zone tissue and 0.44 and 0.36 min(-1) for regions suspected of tumor respectively. Therefore, robust quantification of K-trans values from DCE-MRI exams in the cancerous prostate is feasible with the use of AIF(PHASE). Magn Reson Med 66: 1267-1274, 2011. (C) 2011 Wiley Periodicals, Inc.
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