期刊
MAGNETIC RESONANCE IN MEDICINE
卷 67, 期 6, 页码 1776-1781出版社
WILEY
DOI: 10.1002/mrm.23150
关键词
T1 mapping; B1 correction; dGEMRIC; cartilage
Delayed gadolinium-enhanced MRI of cartilage is a technique for studying the development of osteoarthritis using quantitative T1 measurements. Three-dimensional variable flip angle is a promising method for performing such measurements rapidly, by using two successive spoiled gradient echo sequences with different excitation pulse flip angles. However, the three-dimensional variable flip angle method is very sensitive to inhomogeneities in the transmitted B1 field in vivo. In this study, a method for correcting for such inhomogeneities, using an additional B1 mapping spin-echo sequence, was evaluated. Phantom studies concluded that three-dimensional variable flip angle with B1 correction calculates accurate T1 values also in areas with high B1 deviation. Retrospective analysis of in vivo hip delayed gadolinium-enhanced MRI of cartilage data from 40 subjects showed the difference between three-dimensional variable flip angle with and without B1 correction to be generally two to three times higher at 3 T than at 1.5 T. In conclusion, the B1 variations should always be taken into account, both at 1.5 T and at 3 T. Magn Reson Med, 2011. (c) 2011 Wiley-Liss, Inc.
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