期刊
MAGNETIC RESONANCE IN MEDICINE
卷 67, 期 1, 页码 269-277出版社
WILEY
DOI: 10.1002/mrm.22997
关键词
rotating frame relaxation; glioma; gene therapy; contrast imaging; fictitious field
资金
- National Institute of Health [P30 NS057091, P41 RR008079, R01 NS061866, R21 NS059813]
- Instrumentarium Science Foundation
- Orion Corporation Research Foundation
- Finnish Cultural Foundation Northern Savo
- NATIONAL CENTER FOR RESEARCH RESOURCES [P41RR008079] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE [R21NS059813, R01NS061866, P30NS057091] Funding Source: NIH RePORTER
Longitudinal and transverse rotating-frame relaxation time constants, T1 and T2, have previously been successfully applied to detect gene therapy responses and acute stroke in animal models. Those experiments were performed with continuous-wave irradiation or with frequency-modulated pulses operating in an adiabatic regime. The technique called Relaxation Along a Fictitious Field (RAFF) is a recent extension of frequency-modulated rotating-frame relaxation methods. In RAFF, spin locking takes place along a fictitious magnetic field, and the decay rate is a function of both T1 and T2 processes. In this work, the time constant characterizing water relaxation with RAFF (TRAFF) was evaluated for its utility as a marker of response to gene therapy in a rat glioma model. To investigate the sensitivity to early treatment response, we measured several rotating-frame and free-precession relaxation time constants and the water apparent diffusion coefficients, and these were compared with histological cell counts in 8 days of treated and control groups of animals. TRAFF was the only parameter exhibiting significant association with cell density in three different tumor regions (border, intermediate, and core tissues). These results indicate that TRAFF may provide a marker to identify tumors responding to treatment. Magn Reson Med, 2011. (C) 2011 Wiley-Liss, Inc.
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