期刊
MAGNETIC RESONANCE IN MEDICINE
卷 66, 期 5, 页码 1422-1431出版社
WILEY-BLACKWELL
DOI: 10.1002/mrm.22914
关键词
TOMROP; relaxation time; transfer constant; Patlak plot; 9L glioblastoma
资金
- MRI Biomarkers of Response in Cerebral Tumors [R01 CA135329-01]
- MRI Measures of Blood Brain Barrier Permeability [RO1 HL70023-01A1]
- MRI of Acute Vascular Injury and Hemorrhagic Transformation in Ischemic Stroke [RO1 NS058630-01A2]
The apparent forward transfer constant, K(a)(trans), for albumin was measured in 9L cerebral tumors in 15 rats. An MRI study using gadolinium-labeled bovine serum albumin was followed by terminal quantitative autoradiography (QAR) using radioiodinated serum albumin. Look-Locker MRI estimates of T(1) followed gadolinium-labeled bovine serum albumin blood and tissue concentration. QAR and MRI maps of K(a)(trans) were coregistered, a region of interest (ROI) that included the tumor and its surround was selected, and the two estimates of K(a)(trans) from the ROI on QAR and MRI maps were compared by either mean per animal ROI or on pixel-by-pixel data using a generalized estimating equation. An ROI analysis showed a moderate correlation between the two measures (r = 0.57, P = 0.026); pixel-by-pixel generalized estimating equation analysis concurred (r = 0.54, P < 0.0001). The estimates of QAR with MRI of last time points (e. g., 25 min) showed a moderate correlation (ROI r = 0.55, P < 0.035; generalized estimating equation r = 0.58, P < 0.0001). Differences between the QAR and MRI estimates of K(a)(trans) did not differ from zero, but the MRI 25-min estimate was significantly lower than the QAR estimate. Thus, noninvasive MRI estimates of vascular permeability can serve as a surrogate for QAR measures. Magn Reson Med 66: 1422-1431, 2011. (C) 2011 Wiley Periodicals, Inc.
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