期刊
MAGNETIC RESONANCE IN MEDICINE
卷 65, 期 1, 页码 120-U3出版社
WILEY
DOI: 10.1002/mrm.22601
关键词
arterial transit time; tissue transit time; ASL MRI; cerebral blood flow; spin compartment; T2 relaxation
资金
- NIH [MH084021, AG033106, EB007821, AG034318]
- NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING [R21EB007821] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF MENTAL HEALTH [R01MH084021] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE [R01NS067015] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE ON AGING [R21AG034318, R01AG033106] Funding Source: NIH RePORTER
A major difference between arterial-spin-labeling MRI and gold-standard radiotracer blood flow methods is that the compartment localization of the labeled spins in the arterial-spin-labeling image is often ambiguous, which may affect the quantification of cerebral blood flow. In this study, we aim to probe whether the spins are located in the vascular system or tissue by using T2 of the arterial-spin-labeling signal as a marker. We combined two recently developed techniques, pseudo-continuous arterial spin labeling and T2-Relaxation-Under-Spin-Tagging, to determine the T2 of the labeled spins at multiple postlabeling delay times. Our data suggest that the labeled spins first showed the T2 of arterial blood followed by gradually approaching and stabilizing at the tissue T2. The T2 values did not decrease further toward the venous T2. By fitting the experimental data to a two-compartment model, we estimated gray matter cerebral blood flow, arterial transit time, and tissue transit time to be 74.0 +/- 10.7 mL/100g/min (mean +/- SD, N = 10), 938 +/- 156 msec, and 1901 +/- 181 msec, respectively. The arterial blood volume was calculated to be 1.18 +/- 0.21 mL/100 g. A postlabeling delay time of 2 s is sufficient to allow the spins to completely enter the tissue space for gray matter but not for white matter. Magn Reson Med 65:120-127, 2011. (c) 2010 Wiley-Liss, Inc.
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