期刊
MAGNETIC RESONANCE IN MEDICINE
卷 63, 期 2, 页码 427-437出版社
WILEY
DOI: 10.1002/mrm.22241
关键词
susceptibility; positive contrast; SPIO; cell tracking; SSFP
资金
- National Institutes of Health [R01 HL039297, R01 HL075803]
There has been recent interest in positive-contrast MRI methods for noninvasive tracking of cells labeled with superparamagnetic iron-oxide nanoparticles. Low-tip-angle balanced steady-state free precession sequences have been used for fast, high-resolution, and flow-insensitive positive-contrast imaging; however, the contrast can be compromised by the limited suppression of the on-resonant and fat signals. In this work, a new technique that produces positive contrast with alternating repetition time steady-state free precession is proposed to achieve robust background suppression for a broad range of tissue parameters. In vitro and in vivo experiments demonstrate the reliability of the generated positive contrast. The results indicate that the proposed method can enhance the suppression level by up to 18 dB compared with conventional balanced steady-state free precession. Magn Reson Med 63:427-437, 2010. (C) 2010 Wiley-Liss, Inc.
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