期刊
MAGNETIC RESONANCE IN MEDICINE
卷 63, 期 2, 页码 303-311出版社
WILEY
DOI: 10.1002/mrm.22224
关键词
intermolecular double-quantum coherences (iDQCs); inhomogeneous broadening; high-resolution; localized spectroscopy; human cerebellum
资金
- National Institutes of Health [NS41048]
- NNSF of China [10774125]
- Division of Computing and Communication Foundations
- Direct For Computer & Info Scie & Enginr [0844812] Funding Source: National Science Foundation
Signals from intermolecular double-quantum coherence (iDQCs) have been shown to be insensitive to macroscopic field inhomogeneities and thus enable acquisition of high resolution MR spectroscopy in the presence of large inhomo geneous fields. In this paper, localized iDQC H-1 spectroscopy on a whole-body 3-T MR scanner is reported. Experiments with a brain metabolite phantom were performed to quantify characteristics of the iDQC signal under different conditions. The feasibility of in vivo iDQC high-resolution MR spectroscopy in the presence of large intrinsic and external field inhomogeneity (in the order of hundreds of hertz) was demonstrated in the whole cerebellum of normal volunteers in a scan time of about 6.5 min. Major metabolite peaks were well resolved in the reconstructed one-dimensional spectra projected from two-dimensional iDQC acquisitions. Investigations on metabolite ratios signal-to-noise ratio, and line width were performed and compared with results obtained with conventional point-resolved spectroscopy/MR spectroscopy in homogeneous fields Metabolite ratios from iDQC results showed excellent consistency under different in vitro and in vivo conditions, and they were similar to those from point-resolved spectroscopy with small voxel sizes in homogeneous fields. MR spectroscopy with iDQCs can be applied potentially for quantification of gross metabolite changes due to diseases in large brain volumes with high field inhomogeneity. Magn Reson Med 63:303-311, 2010. (C) 2010 Wiley-Liss, Inc.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据