期刊
MAGNETIC RESONANCE IN MEDICINE
卷 61, 期 1, 页码 222-228出版社
JOHN WILEY & SONS INC
DOI: 10.1002/mrm.21803
关键词
MRI; fMRI; epilepsy; electrode; brain stimulation
资金
- National Institutes of Health (NIH) [RO1 EB002085]
- Canadian Institutes of Health Research [FIN 79260]
- Natural Sciences and Engineering Research Council of Canada
- Alberta Heritage Foundation
- NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING [R01EB002085] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE [R01NS044171] Funding Source: NIH RePORTER
There is a need for acute and chronic stimulation of the brain within the MRI for studies of epilepsy, as well as deep brain stimulation for movement and behavioral disorders. This work describes the production and characteristics of carbon fiber-based electrodes for acute and chronic stimulation in the brain. Increasing MRI field strengths are making it increasingly difficult to introduce foreign objects without a susceptibility artifact. We describe the production of, and the characteristics of carbon fiber-based electrodes. These are biocompatible and can be implanted for chronic studies. We show the use of these electrodes at 9.4T for studying functional activation. Data are presented showing regional connectivity. Activation not only occurs near the electrode, but at sites distant and often contralateral to the electrode. In addition, there were sites showing strong negative activation to stimulation both with direct stimulation and during a kindling-associated seizure. Magn Reson Med 61:222-228, 2009. (C) 2008 Wiley-Liss, Inc.
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