期刊
MAGNETIC RESONANCE IN MEDICINE
卷 61, 期 4, 页码 842-850出版社
WILEY
DOI: 10.1002/mrm.21896
关键词
prostate carcinoma (PCa); diffusion tensor imaging (DTI); apparent diffusion coefficient (ADC); fractional anisotropy (FA)
资金
- Washington University Small Animal Imaging Resource [R24 CA83060]
- Small Animal Imaging Core of the Alvin J. Siteman Cancer Center - a NCI Comprehensive Cancer Center [P30 CA91842]
- NINDS center core [P30 NS048056]
- U.S. Army DOD Prostate Cancer Program Pre-doctoral Fellowship [PC050667]
- Midwest Stone Institute
- NATIONAL CANCER INSTITUTE [R24CA083060, P30CA091842] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE [P30NS048056, R01NS047592, R01NS054194] Funding Source: NIH RePORTER
The contrast provided by diffusion-sensitive magnetic resonance offers the promise of improved tumor localization in organ-confined human prostate cancer (PCa). Diffusion tensor imaging (DTI) measurements of PCa were performed in vivo, in patients undergoing radical prostatectomy, and later, ex vivo, in the same patients' prostatectomy specimens. The imaging data were coregistered to histological sections of the prostatectomy specimens, thereby enabling unambiguous characterization of diffusion parameters in cancerous and benign tissues. Increased cellularity, and hence decreased luminal spaces, in peripheral zone PCa led to approximately 40% and 50% apparent diffusion policy (ADC) decrease compared with benign peripheral zone tissues in vivo and ex vivo, respectively. In contrast, no significant diffusion anisotropy differences were observed between the cancerous and noncancerous peripheral zone tissues. However, the dense fibromuscular tissues in prostate, such as stromal tissues in benign prostatic hyperplasia in central gland, exhibited high diffusion anisotropy. A tissue classification method is proposed to combine DTI and T2-weighted image contrasts that may provide improved specificity of PCa detection over T2-weighted imaging alone. PCa identified in volume rendered MR images qualitatively correlates well with histologically determined PCa foci. Magn Reson Med 61:842-850, 2009. (C) 2009 Wiley-Liss, Inc.
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