期刊
MAGNETIC RESONANCE IN MEDICINE
卷 62, 期 4, 页码 910-923出版社
WILEY
DOI: 10.1002/mrm.22073
关键词
q-ball imaging; fiber tracking; ODF; HARDI
资金
- Intramural NIH HHS Funding Source: Medline
Q-ball imaging is widely used to determine fiber directions for fiber tracking. In cl-ball imaging the directional dependence of water diffusion in tissue is described by Tuch's orientation distribution function (ODF); a different function, the cl-ball orientation distribution function, is measured using high angular resolution magnetic resonance diffusion imaging (HARDI). Tuch's ODF is assumed to be well approximated by the cl-ball ODF. In this study it is shown that 1) the cl-ball ODF is not a good approximation to Tuch's ODF; 2) the properties of the q-ball ODF depend strongly on q, the area of the diffusion sensitization gradients; and 3) the cl-ball ODF for a composite system is the weighted average of the cl-ball ODFs for each subsystem, but the weighting factor is the product of the percent composition and a renormalization factor. In addition, a derivation is presented of the cl-ball ODF for a system described by a Gaussian distribution and expressions are derived for both the dependence of the angular resolution on q and for the relation between the angular resolution and the signal loss. These findings might be useful in the design and interpretation of fiber-tracking experiments. Magn Reson Med 62.910-923, 2009. (C) 2009 Wiley-Liss, Inc.
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