期刊
MAGNETIC RESONANCE IN MEDICINE
卷 61, 期 1, 页码 22-27出版社
JOHN WILEY & SONS INC
DOI: 10.1002/mrm.21827
关键词
magnetization transfer; spinal cord; MT exchange; adrenomyeloneuropathy
资金
- NCRR NIH HHS [P41 RR015241-02S2, RR015241, P41 RR015241] Funding Source: Medline
- NIBIB NIH HHS [P41 EB015909] Funding Source: Medline
- NATIONAL CENTER FOR RESEARCH RESOURCES [P41RR015241] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING [P41EB015909] Funding Source: NIH RePORTER
Magnetization transfer (MT) imaging has assessed myelin integrity in the brain and spinal cord; however, quantitative MT (qMT) has been confined to the brain or excised tissue. We characterized spinal cord tissue with qMT in vivo, and as a first application, qMT-derived metrics were examined in adults with the genetic disorder Adrenomyeloneuropathy (AMN). AMN is a progressive disease marked by demyelination of the white matter tracts of the cervical spinal cord, and a disease in which conventional MRI has been limited. MT data were acquired at 1.5 Tesla using 10 radiofrequency offsets at one power in the cervical cord at C2 in 6 healthy volunteers and 9 AMN patients. The data were fit to a two-pool MT model and the macromolecular fraction (M(ob)), macromolecular transverse relaxation time (T(2b)) and the rate of MT exchange (R) for lateral and dorsal column white matter and gray matter were calculated. Mob for healthy volunteers was: WM = 13.9 +/- 2.3%, GM = 7.9 +/- 1.5%. In AMN, dorsal column M(ob) was significantly decreased (P < 0.03). T(2b) for volunteers was: 9 +/- 2 mu s and the rate of MT exchange (R) was: WM = 56 +/- 11 Hz, GM = 67 +/- 12 Hz. Neither T(2b) nor R showed significant differences between healthy and diseased cords. Comparisons are made between qMT, and conventional MT acquisitions. Magn Reson Med 61:22-27, 2009. (C) 2008 Wiley-Liss, Inc.
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