期刊
MAGNETIC RESONANCE IN MEDICINE
卷 62, 期 5, 页码 1349-1355出版社
WILEY
DOI: 10.1002/mrm.22127
关键词
positive contrast; MRI; SPIO; paramagnetic; contrast agents
资金
- National Institutes of Health [R01-EB005740, P50-ES012359]
- National Institute of Biomedical Imaging and Bioengineering [P41 EB-001977]
Iron oxide-based MRI contrast agents are increasingly being used to noninvasively track cells, target molecular epitopes, and monitor gene expression in vivo. Detecting regions of contrast agent accumulation can be challenging if resulting contrast is subtle relative to endogenous tissue hypointensities. A postprocessing method is presented that yields enhanced positive-contrast images from the phase map associated with T-2*-weighted MRI data. As examples, the method was applied to an agarose gel phantom doped with superparamagnetic iron-oxide nanoparticles and in vivo and ex vivo mouse brains inoculated with recombinant viruses delivering transgenes that induce overexpression of paramagnetic ferritin. Overall, this approach generates images that exhibit a 1- to 8-fold improvement in contrast-to-noise ratio in regions where paramagnetic agents are present compared to conventional magnitude images. This approach can be used in conjunction with conventional T-2* pulse sequences, requires no prescans or increased scan time, and can be applied retrospectively to previously acquired data. Magn Reson Med 62:1349-1355, 2009. (C) 2009 Wiley-Liss, Inc.
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