期刊
MAGNETIC RESONANCE IN MEDICINE
卷 59, 期 5, 页码 973-979出版社
WILEY
DOI: 10.1002/mrm.21539
关键词
adiabatic; high-field; MRSI; B-1; inhomogeneity; 7T; spectral interleaving
资金
- NCRR NIH HHS [RR 09784, P41 RR009784, P41 RR009784-14] Funding Source: Medline
- NIMH NIH HHS [R01 MH080913, R01 MH080913-01A1] Funding Source: Medline
Proton magnetic resonance spectroscopic Imaging (H-1 MRSI) is a useful technique for measuring metabolite levels in vivo, with Choline (Cho), Creatine (Cre), and N-Acetyl-Aspartate (NAA) being the most prominent MRS-detectable brain biochemicals. H-1 MRSI at very high fields, such as 7T, offers the advantages of higher SNR and improved spectral resolution. However, major technical challenges associated with high-field systems, such as increased B, and B-0 inhomogeneity as well as chemical shift localization (CSL) error, degrade the performance of conventional H-1 MRSI sequences. To address these problems, we have developed a Position Resolved Spectroscopy (PRESS) sequence with adiabatic spatial-spectral (SPSP) refocusing pulses, to acquire multiple narrow spectral bands in an interleaved fashion. The adiabatic SPSP pulses provide magnetization profiles that are largely invariant over the 40% B, variation measured across the brain at 7T. Additionally, there is negligible CSL error since the transmit frequency is separately adjusted for each spectral band. In vivo H-1 MRSI data were obtained from the brain of a normal volunteer using a standard PRESS sequence and the interleaved narrow-band PRESS sequence with adiabatic refocusing pulses. In comparison with conventional PRESS, this new approach generated high-quality spectra from an appreciably larger region of interest and achieved higher overall SNR.
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