Monoterpenoid glucoindole alkaloids and iridoids from Pterocephalus pinardii

A new secondary metabolite, pterocephaline, along with the known cantleyoside, 7 alpha-morroniside, 3 beta,5 alpha-tetrahydrodesoxycordifoline lactam, 5S-5-carboxyvincoside, sweroside, and loganin have been isolated from the aerial parts of P. pinardii (Dipsacaceae). Moreover, cantleyoside-methyl-herniacetal and cantleyoside-dimethyl-acetal were obtained as seco-iridoid artifacts. The structures were elucidated by extensive spectroscopic methods including 1D-(H-1, C-13 and TOCSY) and 2D-NMR (DQF-COSY, HSQC and HMBC). Monoterpenoid glucoindole alkaloids were encountered for the first time in Dipsacaceae family. Copyright (c) 2010 John Wiley & Sons, Ltd.