期刊
MAGNETIC RESONANCE IMAGING CLINICS OF NORTH AMERICA
卷 26, 期 4, 页码 479-+出版社
W B SAUNDERS CO-ELSEVIER INC
DOI: 10.1016/j.mric.2018.06.002
关键词
Quantitative; Whole body; Diffusion; DWI; MR Imaging
Whole-body diffusion-weighted MRI has emerged as a powerful diagnostic tool for disease detection and staging mainly used in systemic bone disease. The large field-of-view functional imaging technique highlights cellular tumor and suppresses normal tissue signal, allowing quantification of an estimate of total disease burden, summarized as the total diffusion volume (tDV), as well as global apparent diffusion coefficient (gADC) measurements. Both tDV and gADC have been shown to be repeatable quantitative parameters that indicate tumor heterogeneity and treatment effects, thus potential, noninvasive, imaging biomarkers informing on disease prognosis and therapy response.
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