期刊
MAGNETIC RESONANCE IMAGING
卷 30, 期 7, 页码 907-915出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.mri.2012.03.006
关键词
Cortical lesions; White matter; MRI; 7 T; Optimization
资金
- NINDS NIH HHS [F31 NS071898] Funding Source: Medline
Cortical lesions have recently been a focus of multiple sclerosis (MS) MR research. In this study, we present a white matter signal attenuating sequence optimized for cortical lesion detection at 7 T. The feasibility of white matter attenuation (WHAT) for cortical lesion detection was determined by scanning eight patients (four relapsing/remitting MS, four secondary progressive MS) at 7 T. WHAT showed excellent gray matter-white matter contrast, and cortical lesions were hyperintense to the surrounding cortical gray matter, The sequence was then optimized for cortical lesion detection by determining the set of sequence parameters that produced the best gray matter-cortical lesion contrast in a 10-min scan. Despite the B1 inhomogeneities common at ultra-high field strengths, WHAT with an adiabatic inversion pulse showed good cortical lesion detection and would be a valuable component of clinical MS imaging protocols. (C) 2012 Elsevier Inc. All rights reserved.
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