期刊
MAGNETIC RESONANCE IMAGING
卷 26, 期 7, 页码 870-873出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.mri.2008.01.041
关键词
EEG-fMRI; generalized spike wave; BOLD; perfusion; correlation; neurovascular coupling
资金
- MRC [G9805989, G0301067] Funding Source: UKRI
- Medical Research Council [G9805989, G0200216, G0301067] Funding Source: researchfish
- Medical Research Council [G9805989, G0200216, g0301067, G0301067] Funding Source: Medline
- Wellcome Trust [075929, 067176] Funding Source: Medline
In pathological conditions interpretation of functional magnetic resonance imaging (WRI) results can be difficult. This is due to a reliance on the assumed coupling between neuronal activity and changes in cerebral blood flow (CBF) and oxygenation. We wanted to investigate the coupling between blood oxygen level dependant contrast (BOLD) and CBF time courses in epilepsy patients with generalised spike wave activity (GSW) to better understand the underlying mechanisms behind the EEG-fMRI signal changes observed, especially in regions of negative BOLD response (NBR). Four patients with frequent GSW were scanned with simultaneous electroencephalographic (EEG)-fMRI with BOLD and arterial spin labeling (ASL) sequences. We examined the relationship between simultaneous CBF and BOLD measurements by looking at the Correlation of the two signals in terms of percentage signal change on a voxel-by-voxel basis. This method is not reliant on coincident activation. BOLD and CBF were positively correlated in patients with epilepsy during background EEG activity and GSW The subject average value of the Delta CBF/Delta BOLD slope lay between +19 and +36 and also showed spatial variation which could indicate areas with altered vascular response. There was not a significant difference between Delta CBF/Delta BOLD during GSW, suggesting that neurovascular Coupling to BOLD signal is generally maintained between states and, in particular, within areas of NBR. (c) 2008 Elsevier Inc. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据