期刊
MAGNETIC RESONANCE IMAGING
卷 26, 期 7, 页码 897-904出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.mri.2008.01.042
关键词
high-b diffusion imaging; biexponential signal decay; cortical bray matter; deep gray matter; line scan diffusion imaging; FLAIR
资金
- NCRR NIH HHS [U41 RR019703] Funding Source: Medline
- NIBIB NIH HHS [R01 EB006867, R01 EB006867-06] Funding Source: Medline
- NINDS NIH HHS [R01 NS39335, R01 NS039335] Funding Source: Medline
Diffusion imaging with high-b factors, high spatial resolution and cerebrospinal fluid signal suppression was performed in order to characterize the biexponential nature of the diffusion-related signal decay with b-factor in normal cortical gray and deep gray matter (GM). Integration of inversion Pulses with a line scan diffusion imaging sequence resulted in 91% cerebrospinal fluid signal Suppression, permitting accurate measurement of the fast diffusion coefficient in cortical GM (1.142 +/- 0.106 mu m(2)/ms) and revealing a marked similarity with that found in frontal white matter (WM) (1.1 55 +/- 0.046 mu m(2)/ms). The reversal of contrast between GM and WM at low vs high b-factors is shown to be due to it significantly faster slow diffusion coefficient in cortical GM (0.338 +/- 0.027 mu m(2)/ms) than in frontal WM (0.125 +/- 0.014 mu m(2)/ms). The same characteristic diffusion differences between GM and WM are observed in other brain tissue structures. The relative component size showed nonsignificant differences among all tissues investigated. Cellular architecture in GM and WM are fundamentally different and may explain the two- to threefold higher slow diffusion coefficient in Gm. (C) 2008 Elsevier Inc. All rights reserved.
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