Synthesis of Multifunctional Polymers through the Ugi Reaction for Protein Conjugation

The Ugi reaction has been utilized as a multicomponent click reaction to efficiently synthesize a series of multifunctional PEGylation agents, and those PEG derivatives were successfully conjugated on a protein surface to generate corresponding multifunctional protein polymer conjugates, indicating the promising potential of the Ugi reaction in the field of PEGylation.