期刊
MACROMOLECULES
卷 41, 期 16, 页码 5997-6005出版社
AMER CHEMICAL SOC
DOI: 10.1021/ma800976e
关键词
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资金
- Research Grants Council of Hong Kong [602707, 602706, HKU2/05C]
- Ministry of Science & Technology of China [200203613401]
- National Natural Science Foundation of China [20634020]
A functional phenylacetylene monomer containing a naturally occurring building block Of L-alanine, namely 4-ethynylbenzoyl-L-alanine methyl ester (PA-Ae), was synthesized. The monomer was polymerized by organorhodium catalysts, giving the corresponding polyester (PPA-Ae) with high molecular weights (M-w up to 1.2 x 10(6)) and stereoregularities (Z content up to 97%) in high yields (up to similar to 91 %). The polyene backbone of PPA-Ae undergoes irreversible Z-to-E isomerization at similar to 180-250 degrees C. The ester groups in the pendants of the polymer are selectively deprotected by the base-catalyzed hydrolysis, producing a polyacid with free L-alanine pendants (PPA-A). While PA-Ae monomer is CD-inactive at wavelengths longer than 300 nm, both PPA-Ae and PPA-A polymers exhibit strong Cotton effects in the long wavelength region where their polyene backbones absorb, indicating that the chiral pendants have induced the polymer chain to take a helical conformation with an excess in one-handedness. Upon natural evaporation of its solutions, the amphiphilic chains of PPA-Ae self-associate in a cooperative fashion, furnishing a variety of organizational morphologies including twisting cables, spiral ribbons, spherical vesicles, and helical nanotubes. The polymers are biocompatible: the living cells are all survived after they have been subcultured in the presence of the polymers.
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