期刊
MACROMOLECULAR RESEARCH
卷 17, 期 2, 页码 79-83出版社
POLYMER SOC KOREA
DOI: 10.1007/BF03218658
关键词
sodium deoxycholate; oral delivery; heparin; conjugate
资金
- Ministry of Health & Welfare, Republic of Korea [A060699]
- Korea Health Promotion Institute [A060699] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
The oral delivery of heparin is the preferred therapy hi the treatment of patients with a high risk of deep vein thrombosis and pulmonary embolism. New conjugates of heparin and sodium deoxycholate were synthesized in order to enhance the heparin absorption in the GI tract. After oral administration of DOC-heparin, the concentration in anti-FXa assay was increased with increasing amount Of Coupled DOC. The maximum concentration of DOC-heparin VIII conjugate was 3.3 +/- 0.5 IU/mL at an oral dose of 10 mg/kg, which was 3-fold higher than the baseline level. Finally, DOC coupled to heparin greatly enhanced the absorption of heparin in the GI tract, and this enhancing effect was not induced by changing the tissue structure of the GI wall.
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