期刊
MACROMOLECULAR RAPID COMMUNICATIONS
卷 35, 期 24, 页码 2089-2095出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/marc.201400477
关键词
dynamic covalent hydrogels; hyaluronic acid; phenylboronate esters; polysaccharides; rheology
资金
- Agence Nationale pour la Recherche (ANR P3N program)
- ICMG [FR 2607]
Dynamic covalent hydrogels are facilely prepared from biocompatible polysaccharides in physiological conditions by the formation of phenylboronate ester cross-links. This is based on the simple mixing of carboxylate-containing polysaccharides (i.e., hyaluronic acid or carboxymethylcellulose) modified with phenylboronic acid and maltose moieties according to mild coupling reactions performed in aqueous solution. The formation of dynamic networks based on reversible boronic-ester cross-links is demonstrated by analyzing their rheological behavior. This study shows that these gels can adapt their structure in response to chemical stimuli such as variations in pH or addition of glucose and self-heal.
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