期刊
MACROMOLECULAR RAPID COMMUNICATIONS
卷 35, 期 14, 页码 1255-1259出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/marc.201400078
关键词
colloids; nanoparticles; nanotechnology; self-assembly; stimuli-sensitive polymers
资金
- Program for New Century Excellent Talents in University [NCET-11-0582]
- Fundamental Research Funds for the Central Universities [FRF-TP-12-004B]
- National Natural Science Foundation of China [51373025, 21074010]
Polymer nanoparticles are prepared by self-assembly of visible light and pH sensitive perylene-functionalized copolymers which are synthesized by quaternization between 1-(bromomethyl) perylene and the dimethylaminoethyl units of poly(dimethylaminoethyl methacrylate) (PDMAEMA). The perylene-containing polymethacrylate segments afford the system visible light responsiveness and the unquaternized PDMAEMA segments afford the system pH responsiveness. The self-assembled nanoparticles exhibit a unique dual stimuli response. They can be photocleaved under visible light irradiation, shrunken to smaller nanoparticles at high pH, and swollen at low pH. The structural change endows the nano-particle with great potential as a sensitive nanocarrier for controlled release of Nile Red and lysozyme under this stimulation. The visible light responsiveness and synergistic effect on the release of loaded molecules with the dual stimulation may obviate the need for harsh conditions such as UV light or extreme pH stimulation, rendering the system more applicable under mild conditions.
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