期刊
MACROMOLECULAR RAPID COMMUNICATIONS
卷 35, 期 6, 页码 624-629出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/marc.201300868
关键词
cell uptake; nanoparticle; poly(methyl vinyl ether-alt-maleic acid); porous silicon; stability
资金
- Academy of Finland [252215, 256394]
- University of Helsinki
- European Research Council under the European Union [310892]
- Academy of Finland (AKA) [256394, 256394] Funding Source: Academy of Finland (AKA)
Currently, developing a stable nanocarrier with high cellular internalization and low toxicity is a key bottleneck in nanomedicine. Here, we have developed a successful method to covalently conjugate poly(methyl vinyl ether-co-maleic acid) (PMVE-MA) copolymer on the surface of (3-aminopropyl)triethoxysilane-functionalized thermally carbonized porous silicon nanoparticles (APSTCPSi NPs), forming a surface negatively charged nanovehicle with unique properties. This polymer conjugated NPs could modify surface smoothness, charge, and hydrophilicity of the developed NPs, leading to considerable improvement in the colloidal and plasma stabilities via enhanced suspensibility and charge repulsion. Furthermore, despite the surface negative charge of the polymer-conjugated NPs, the cellular internalization was increased in both MDA-MB-231 and MCF-7 breast cancer cells. These results provide a proof-of-concept evidence that such polymer-based PSi nanocomposite can be extensively used as a promising candidate for intracellular drug delivery. image
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